![]() ![]() The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. 49ers picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine. The Niners are listed as 14-point favorites and the over/under for total points scored is 43.5 points in the latest 49ers vs. Kickoff from Levi's Stadium is scheduled for 4:25 p.m. San Francisco won both matchups during the 2022 season, 38-10 in Week 11 and 38-13 in Week 18. San Francisco, 3-0, enters off a 30-12 victory over the New York Giants last Thursday night, while Arizona, 1-2, defeated the Dallas Cowboys as a 12.5-point underdog at home last Sunday, 28-16. ![]() San Francisco 49ers' quarterback Brock Purdy looks to continue his undefeated regular season streak as he faces his hometown team, the Arizona Cardinals on Sunday afternoon in the Bay Area. ![]()
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